The Mitochondrial K Channel as a Receptor for Potassium Channel Openers
نویسندگان
چکیده
منابع مشابه
Is there a therapeutic future for "potassium channel openers'?
1. Potassium channels, which control cell electrical activity, are among the most regulated of all ion channels in biology. Promotion of activity in K+ channels by a wide range of physiological factors tends to stabilize cell function. 2. The discovery of synthetic molecules (e.g. cromakalim) that 'directly' open ATP-sensitive K+ channels has led to a new direction in pharmacology. ATP-sensitiv...
متن کاملPotassium Channel Openers Agents for the Treatment of Airway Hyperreactivity
77 Summary ATP-sensitive potassium (KATP) channels link the metabolic status of the cell to the plasma membrane potential and thus play a key role in regulating cellular excitability. KATP channel openers (KCOs) may impact positively on respiratory disease by suppressing bronchoconstriction, mucus hypersecretion, cough and airway hyperreactivity (AHR). A major recent development is the emergenc...
متن کاملLarge-conductance K+ channel openers NS1619 and NS004 as inhibitors of mitochondrial function in glioma cells.
Recently, it has been reported that large-conductance Ca(2+)-activated potassium channels, also known as BK(Ca)-type potassium channels, are present in the inner mitochondrial membrane of the human glioma LN229 cell line. Hence, in the present study, we have investigated whether BK(Ca)-channel openers (BK(Ca)COs), such as the benzimidazolone derivatives NS004 (5-trifluoromethyl-1-(5-chloro-2-hy...
متن کاملMechanisms of action of various ATP-sensitive potassium channel openers.
Dr. Grover’s very kind and complimentary remarks about the recent review [l] on ATP-sensitive potassium channel openers during ischemia and reperfusion are much appreciated. One point, however, causes Dr. Grover considerable concern-this is the citation of (and by implication a presumed agreement with) the comments in the paper by Richer et al. [2]. This paper was critical of the conclusions of...
متن کاملSynthesis and Vasorelaxant Effect of 9-aryl-1,8-acridinediones as Potassium Channel Openers in Isolated Rat Aorta
ATP-sensitive potassium (KATP) channel openers have a relaxation effect due to the lower cellular membrane potential and inhibit calcium influx. There has been considerable interest in exploring KATP channel openers in the treatment of various diseases such as cardiovascular, cerebrovascular, and urinary system disease and premature labor. The purpose of this study was to synthesize 3,3,6,6-tet...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1996
ISSN: 0021-9258
DOI: 10.1074/jbc.271.15.8796